Bjerre B, Eliasson G, Linell F, Söderberg H, Sjöberg N O
Am J Obstet Gynecol. 1976 May 15;125(2):143-52. doi: 10.1016/0002-9378(76)90584-6.
Knife conization was performed in 2,099 cases with abnormal vaginal smears. The frequency of complications was low. Carcinoma in situ was diagnosed in 1,500 cases and follow-up showed that conization was curative in 87%. The curative rate was depending on whether the resection margins were free of pathologic epithelium or not. If smears were repeatedly negative the first year after conization a new diagnosis of cancer was made in 0.4%. It was not possible to decide whether these lesions were residual changes or true recurrences. Treatment of carcinoma in situ by conization has so far reduced the frequency of invasive cervical cancer by 60%.
对2099例阴道涂片异常的患者实施了宫颈锥形切除术。并发症发生率较低。1500例被诊断为原位癌，随访显示锥形切除术的治愈率为87%。治愈率取决于切除边缘是否无病理上皮。如果锥形切除术后第一年涂片反复呈阴性，新发癌症诊断率为0.4%。无法确定这些病变是残留改变还是真正的复发。迄今为止，通过锥形切除术治疗原位癌已使浸润性宫颈癌的发生率降低了60%。
