Mostov Keith, Su Tao, ter Beest Martin
Department of Anatomy, Genentech Hall, 600 16th Street, University of California, San Francisco, CA 94143-2140, USA.
Nat Cell Biol. 2003 Apr;5(4):287-93. doi: 10.1038/ncb0403-287.
Most cells are polarized and have distinct plasma membrane domains, which are the result of polarized trafficking of proteins and lipids. Great progress has been made in elucidating the highly conserved polarized targeting machinery. A pre-eminent challenge now is to understand the plasticity of polarized traffic, how it is altered by differentiation and dedifferentiation during development, as well as the adaptation of differentiated cells to meet changing physiological needs.
大多数细胞是极化的，具有不同的质膜结构域，这是蛋白质和脂质极化运输的结果。在阐明高度保守的极化靶向机制方面已经取得了很大进展。现在一个突出的挑战是了解极化运输的可塑性，它在发育过程中如何因分化和去分化而改变，以及分化细胞如何适应以满足不断变化的生理需求。
