Butteriss D J A, Ramesh V, Birchall D
Department of Neuroradiology, Regional Neurosciences Centre Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK.
Neuroradiology. 2003 May;45(5):300-3. doi: 10.1007/s00234-003-0979-z. Epub 2003 Mar 27.
We report MRI findings in a patient with familial hemiplegic migraine (FHM) with repeated episodes of hemiparesis. FHM is caused by a penetrant autosomal dominant genetic mutation; several mutations have been genotyped, involving brain-expressed ion channels. We found cerebral oedema, dilatation of intracerebral vessels and decreased water diffusion contralateral to the hemiparesis, not respecting vascular territories, with subsequent complete resolution of both clinical and imaging abnormalities. These results are thought to be consistent with an underlying primary neuronal pathology with secondary vascular effects, as opposed to the traditional, primarily vascular, model of migraine aetiology.
我们报告了一名患有家族性偏瘫性偏头痛（FHM）且反复出现偏瘫发作的患者的MRI检查结果。FHM由显性常染色体显性基因突变引起；已对几种突变进行了基因分型，这些突变涉及在大脑中表达的离子通道。我们发现脑水肿、脑内血管扩张以及偏瘫对侧的水扩散降低，不受血管区域限制，随后临床和影像异常均完全消退。这些结果被认为与潜在的原发性神经元病变及继发性血管效应相符，这与偏头痛病因学的传统主要为血管性的模型相反。
