Song Jinhui, Dai Song
Department of Otorhinolaryngology, Hospital of PLA 463, Shenyang 110042.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Dec;16(12):672-3.
To explore the expression of IL-8 on laryngeal carcinoma and the edge tissues and its relationship with the character of laryngeal carcinoma.
Immunohistochemical SABC detections were carried out in 35 case of original laryngeal cancer and the edge tissues (1.0 cm near the tumor).
The positive rate was 68.6% in 24 case of carcinoma group, 42.9% in 15 case of edge group. The statistical difference between carcinoma group with edge group was very significant(P < 0.05). The expression of IL-8 had no difference in location, tumor developed degree and lymph metastases.
The expression of IL-8 may play an important role in the process of laryngeal cancer and the patients' immune stage.
探讨白细胞介素-8（IL-8）在喉癌组织及其癌旁组织中的表达情况，并分析其与喉癌生物学特性的关系。
采用免疫组织化学SABC法对35例原发性喉癌及其癌旁组织（距肿瘤边缘1.0 cm）进行检测。
癌组织组24例中阳性率为68.6%，癌旁组织组15例中阳性率为42.9%。癌组织组与癌旁组织组之间的统计学差异非常显著（P < 0.05）。IL-8的表达在部位、肿瘤发展程度及淋巴结转移方面无差异。
IL-8的表达可能在喉癌发生发展过程及患者免疫状态中起重要作用。
