Conger J D, Burke T J
Am J Physiol. 1976 Mar;230(3):652-7. doi: 10.1152/ajplegacy.1976.230.3.652.
Controversy has existed over apparent dissimilarities in the autoregulatory capacities of the rat and dog. A protocol was designed to evaluate both the effects of the anesthetic agents. Nembutal (used most commonly in dogs) and Inactin (most frequently employed in rats) and the species peculiarities of these two mammals on autoregulation of renal blood flow (RBF) and glomerular filtration rate (GFR). With Nembutal autoregulation of RBF was present in both experimental animals. Inactin impaired RBF autoregulation similarly in both species. With impaired RBF autoregulation similarly in both species. With either anesthetic GFR was autoregulated well in both rat and dog. Comparison of the two species revealed a greater RBF per gram kidney weight and a higher renal perfusion pressure (RPP) at which autoregulation of both hemodynamic parameters was lost in the rat. It is concluded from these studies that 1) the frequent use of Inactin in the rat in large part accounts for the observed lack of autoregulation of RBF in this animal and 2) renal hemodynamic responses are qualitatively similar in rat and dog when the same anesthetic agents are used.
大鼠和狗的自身调节能力存在明显差异，这一点一直存在争议。设计了一项实验方案，以评估麻醉剂的效果。戊巴比妥（最常用于狗）和安泰酮（最常用于大鼠）以及这两种哺乳动物在肾血流量（RBF）和肾小球滤过率（GFR）自身调节方面的物种特性。使用戊巴比妥时，两种实验动物的RBF均存在自身调节。安泰酮在两种物种中对RBF自身调节的损害相似。两种物种的RBF自身调节均受损。使用任何一种麻醉剂时，大鼠和狗的GFR均能得到良好的自身调节。两种物种的比较显示，每克肾脏重量的RBF更高，并且在大鼠中，两种血流动力学参数的自身调节丧失时的肾灌注压（RPP）更高。从这些研究中可以得出结论：1）在大鼠中频繁使用安泰酮在很大程度上解释了该动物中观察到的RBF缺乏自身调节的现象；2）当使用相同的麻醉剂时，大鼠和狗的肾血流动力学反应在质量上是相似的。
