Baldy-Moulinier M, Besset-Lehmann J, Passouant P
C R Seances Soc Biol Fil. 1975;169(1):126-31.
Intravenous injection of CT 1341 (a mixture of alphaxalone and alphadolone dissolved in cremophor el) induced a decrease in cerebral blood flow (CBF) measured by 133Xe clearance in cats with artificial respiration (the mean reduction in CBF was 2 ml/100 g/mn for 1,2 mg/kg or CT 1341. So, CBF was decreased by 22% when CT 1341 (7,2 mg/kg) was intravenously injected, (mean Pa CO2 equals 30 mm Hg). Changes in CBF following CT 1341 intravenous injection seems to be caused by cerebral vascular constriction evidenced by the direct observation of pial vessels. Following intravenous injection of CT 1341 (from 7, 2 mg/kg to 19,2 mg/kg), the cerebrovascular reactivity to hypercapnia or hypocapnia was not affected, but autoregulation of cerebral blood flow was transiently abolished. In animals with free respiration, CBF was increased in relation with the elevation in Pa CO2 caused by the depression of respiration.
静脉注射CT 1341（一种溶解于聚氧乙烯蓖麻油中的α-羟孕酮和α-孕烷二酮的混合物）可使人工呼吸猫经133Xe清除法测得的脑血流量（CBF）降低（对于1.2mg/kg的CT 1341，CBF平均降低2ml/100g/分钟。因此，静脉注射7.2mg/kg的CT 1341时，CBF降低了22%，（平均动脉血二氧化碳分压等于30mmHg）。静脉注射CT 1341后CBF的变化似乎是由软脑膜血管的直接观察所证实的脑血管收缩引起的。静脉注射CT 1341（从7.2mg/kg至19.2mg/kg）后，脑血管对高碳酸血症或低碳酸血症的反应性未受影响，但脑血流量的自动调节被暂时消除。在自主呼吸的动物中，CBF随着呼吸抑制导致的动脉血二氧化碳分压升高而增加。
