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用于脑循环研究的麻醉:苯环利定与阿法沙龙在狒狒体内的比较。

Anaesthesia for studies of the cerebral circulation: a comparison of phencyclidine and althesin in the baboon.

作者信息

Fitch W, McGeorge A P, MacKenzie E T

出版信息

Br J Anaesth. 1978 Oct;50(10):985-91. doi: 10.1093/bja/50.10.985.

DOI:10.1093/bja/50.10.985
PMID:101224
Abstract

The effects of phencyclidine on cerebral blood flow, cerebral metabolic rate for oxygen and carbon dioxide reactivity were compared with those of Althesin in six baboons. Under similar and stable levels (Stage 1) of electroencephalographic activity cerebral blood flow and the cerebral metabolic rate for oxygen were significantly less during the infusion of Althesin when compared with the values obtained during the infusion of phencyclidine. Reactivity to carbon dioxide was present and similar during the infusion of either drug.

摘要

在六只狒狒身上,将苯环利定对脑血流量、脑氧代谢率和二氧化碳反应性的影响与阿法沙龙的影响进行了比较。在脑电图活动处于相似且稳定水平(第1阶段)时,与输注苯环利定期间获得的值相比,输注阿法沙龙期间脑血流量和脑氧代谢率显著更低。在输注任何一种药物期间,对二氧化碳的反应性均存在且相似。

相似文献

1
Anaesthesia for studies of the cerebral circulation: a comparison of phencyclidine and althesin in the baboon.用于脑循环研究的麻醉:苯环利定与阿法沙龙在狒狒体内的比较。
Br J Anaesth. 1978 Oct;50(10):985-91. doi: 10.1093/bja/50.10.985.
2
Effects of Althesin on cerebral blood flow and oxygen consumption in man.阿尔泰辛对人体脑血流量和氧耗量的影响。
Br J Anaesth. 1976 Jun;48(6):545-50. doi: 10.1093/bja/48.6.545.
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[Changes in regional blood flow of the brain during althesin anaesthesia (author's transl)].阿耳法埃西诺麻醉期间脑局部血流的变化(作者译)
Rev Electroencephalogr Neurophysiol Clin. 1977 Jan-Mar;7(1):98-104. doi: 10.1016/s0370-4475(77)80041-5.
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[Effects of Alfatesine (ct 1341) on cerebral blood flow and metabolism in man. Global and regional changes].[阿法替辛(ct 1341)对人体脑血流量和代谢的影响。整体及局部变化]
Ann Anesthesiol Fr. 1976;17(11):1247-54.
5
Vascular reactivity with althesin (R) in focal cerebral ischemia.
Acta Neurol Scand Suppl. 1977;64:172-3.
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Time course of the cerebral circulatory response to metabolic depression.
Am J Physiol. 1978 Jan;234(1):H74-9. doi: 10.1152/ajpheart.1978.234.1.H74.
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Althesin in neurosurgical patients: effects on cerebral hemodynamics and metabolism.阿尔thesin在神经外科手术患者中的应用:对脑血流动力学和代谢的影响。 (注:原文中Althesin可能是一种特定药物名称,这里按音译处理,可能需要结合专业知识进一步准确翻译该药物名)
Acta Anaesthesiol Scand. 1978;22(3):257-69. doi: 10.1111/j.1399-6576.1978.tb01300.x.
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Control of cerebral vascular smooth muscle during general anaesthesia.
Ciba Found Symp. 1978 Mar(56):257-73. doi: 10.1002/9780470720370.ch14.
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E.E.G. monitoring for the control of anaesthesia produced by the infusion of althesin in primates.
Br J Anaesth. 1978 Oct;50(10):993-1001. doi: 10.1093/bja/50.10.993.
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[Study of the effects of Alfatesin on cerebral blood flow in cats].
Ann Anesthesiol Fr. 1975 Oct;16(6):417-22.

引用本文的文献

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Correlations between visual recognition memory and neocortical and hippocampal glucose metabolism after bilateral rhinal cortex lesions in the baboon: implications for Alzheimer's disease.狒狒双侧嗅皮质损伤后视觉识别记忆与新皮质及海马葡萄糖代谢之间的相关性:对阿尔茨海默病的启示
J Neurosci. 2002 Nov 1;22(21):9166-70. doi: 10.1523/JNEUROSCI.22-21-09166.2002.
2
The effect of sodium salicylate on cerebral blood flow and metabolism.水杨酸钠对脑血流量和代谢的影响。
Br J Pharmacol. 1980 Mar;68(3):407-11. doi: 10.1111/j.1476-5381.1980.tb14554.x.
3
Effects of hypotension induced with sodium nitroprusside on the cerebral circulation before, and one week after, the subarachnoid injection of blood.
硝普钠诱导的低血压对蛛网膜下腔注射血液前及注射后一周脑循环的影响。
J Neurol Neurosurg Psychiatry. 1988 Jan;51(1):88-93. doi: 10.1136/jnnp.51.1.88.
4
Delayed effects of subarachnoid haemorrhage on cerebral metabolism and the cerebrovascular response to hypercapnia in the primate.灵长类动物蛛网膜下腔出血对脑代谢及脑血管对高碳酸血症反应的延迟影响。
J Neurol Neurosurg Psychiatry. 1979 Oct;42(10):892-8. doi: 10.1136/jnnp.42.10.892.