Poole M C, Mahesh V B, Costoff A
Cell Tissue Res. 1981;220(1):131-7. doi: 10.1007/BF00209972.
The crinophagic and autophagic lysosomal systems were studied in mammotropes (prolactin secreting cells) of the adenohypophysis throughout the estrous cycle of the rat. By means of morphometric analysis, it was found that the volume of secondary autophagic lysosomes was usually greater than that of the crinophagic type. Although the volumes of both secondary autophagic and crinophagic lysosomes were minimal throughout proestrus and diestrus 2, the autophagic lysosomal volume per mammotrope was elevated during the estrous period. The volume of secondary crinophagic lysosomes per mammotrope increased during late estrus and remained elevated throughout early diestrus 1. Furthermore, there was an inverse relationship between the volume of mature secretory granules per cell and of the crinophagic system. These data suggest a role for lysosomes in the regulation of synthesis and secretion of prolactin by the adenohypophysis of the rat.
在大鼠整个发情周期中，对腺垂体促乳素分泌细胞（促乳素细胞）中的噬分泌颗粒溶酶体系统和自噬溶酶体系统进行了研究。通过形态计量分析发现，次级自噬溶酶体的体积通常大于噬分泌颗粒溶酶体的体积。尽管在动情前期和动情后期2，次级自噬溶酶体和噬分泌颗粒溶酶体的体积均最小，但在发情期每个促乳素细胞的自噬溶酶体体积会升高。每个促乳素细胞的次级噬分泌颗粒溶酶体体积在发情后期增加，并在动情后期1早期一直保持升高。此外，每个细胞中成熟分泌颗粒的体积与噬分泌颗粒系统的体积之间呈负相关。这些数据表明溶酶体在大鼠腺垂体催乳素的合成和分泌调节中发挥作用。
