Fish J E, Rosenthal R R, Batra G, Menkes H, Summer W, Permutt S, Norman P
Am Rev Respir Dis. 1976 May;113(5):579-86. doi: 10.1164/arrd.1976.113.5.579.
After inhalation challenge with methacholine, bronchoconstrictor responses were produced in allergic subjects with asthma and hay fever as well as nonallergic subjects. Our results indicate that allergic persons possess a greater pulmonary responsiveness to inhalation of this parasympathomimetic agent than nonallergic subjects; however, patterns of response were different in the 2 types of allergic subjects, those with asthma and those with hay fever. Whereas both types of allergic subjects responded with changes in specific airway conductance when nonallergic subjects did not, only asthmatic subjects differed from nonallergic subjects when comparisons of spirometry were made. These data suggest that there is hypersensitivity of both central and peripheral airways in asthmatics and in the larger central airways of nonasthmatic allergic subjects.
在用乙酰甲胆碱进行吸入激发试验后，哮喘和花粉热过敏受试者以及非过敏受试者均出现支气管收缩反应。我们的结果表明，过敏者对吸入这种拟副交感神经药物的肺部反应性比非过敏受试者更高；然而，两种过敏受试者（哮喘患者和花粉热患者）的反应模式有所不同。当非过敏受试者无反应时，两种过敏受试者均出现特定气道传导率的变化，而在进行肺量计比较时，只有哮喘受试者与非过敏受试者不同。这些数据表明，哮喘患者的中央和外周气道以及非哮喘过敏受试者的较大中央气道均存在超敏反应。
