Asakura K, Enomoto K, Ara H, Azuma E, Kataura A
Arch Otorhinolaryngol. 1984;239(3):273-8. doi: 10.1007/BF00464255.
We examined the nasal responsiveness to topical methacholine application in allergic rhinitis and non-allergic chronic rhinitis patients, and in control subjects. Methacholine responsiveness was significantly higher in allergic rhinitis patients than in non-allergic patients and control subjects. In perennial rhinitis, methacholine responsiveness correlated with the severity of daily nasal symptoms and those provoked by specific allergen challenge tests. Among nasal symptoms, hyper-rhinorrhoea was found to be closely related to methacholine responsiveness. As a result of these findings, the possibility of cholinergic hyper-reactivity in allergic rhinitis patients is discussed.
我们研究了变应性鼻炎、非变应性慢性鼻炎患者以及对照受试者对局部应用乙酰甲胆碱的鼻腔反应性。变应性鼻炎患者的乙酰甲胆碱反应性显著高于非变应性患者和对照受试者。在常年性鼻炎中，乙酰甲胆碱反应性与每日鼻部症状的严重程度以及特异性变应原激发试验所诱发的症状相关。在鼻部症状中，发现鼻溢液过多与乙酰甲胆碱反应性密切相关。基于这些发现，讨论了变应性鼻炎患者存在胆碱能性高反应性的可能性。
