从臭椿中分离出三种新的苦木素，即臭椿醇E、F和G。

Three new quassinoids, ailantinol E, F, and G, from Ailanthus altissima.

作者信息

Tamura Sadaaki, Fukamiya Narihiko, Okano Masayoshi, Koyama Junko, Koike Kazuo, Tokuda Harukuni, Aoi Wataru, Takayasu Junko, Kuchide Masashi, Nishino Hoyoku

机构信息

Faculty of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2003 Apr;51(4):385-9. doi: 10.1248/cpb.51.385.

DOI:10.1248/cpb.51.385

PMID:12672989

Abstract

Three new quassinoids, ailantinol E (1), ailantinol F (2), and ailantinol G (3), and related compounds were isolated from Ailanthus altissima grown in Taiwan. Their structures were elucidated from spectral evidence. Each new quassinoid was evaluated for its antitumor promoting effects against Epstein-Barr virus early antigen activation introduced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The new quassinoids were found to show potent activity without showing any cytotoxicity. The screening for inhibitors against nitric oxide donor action was also conducted using the new quassinoids and some standard samples.

摘要

从生长于台湾的臭椿中分离出三种新的苦木素类化合物，即臭椿醇E（1）、臭椿醇F（2）和臭椿醇G（3）以及相关化合物。通过光谱数据阐明了它们的结构。对每种新的苦木素类化合物进行了评估，考察其对12-O-十四烷酰佛波醇-13-乙酸酯在Raji细胞中诱导的爱泼斯坦-巴尔病毒早期抗原激活的抗肿瘤促进作用。发现这些新的苦木素类化合物具有很强的活性，且无任何细胞毒性。还使用这些新的苦木素类化合物和一些标准样品进行了一氧化氮供体作用抑制剂的筛选。