a Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University , Guangzhou 510632 , P.R. China.
Nat Prod Res. 2014;28(18):1432-7. doi: 10.1080/14786419.2014.909418. Epub 2014 Jun 26.
A new quassinoid, shinjulactone O (1), and seven known quassinoids, were isolated from the 50% ethanol extract of the root bark of Ailanthus altissima. The structures of these compounds were determined based on spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR. Their cytotoxic activities were evaluated on the tumour cell lines MCF-7, MDA-MB-231, HepG2 and A549 cells, as well as the normal HUVEC line in vitro. Compounds 1-8 exhibited different levels of inhibitory activity against tumour cell lines.
从臭椿根皮的 50%乙醇提取物中分离得到一个新的羽扇豆烷型二萜化合物 shinjulactone O（1）和 7 个已知的羽扇豆烷型二萜化合物。基于包括 UV、IR、HR-ESI-MS、1D 和 2D NMR 在内的光谱方法确定了这些化合物的结构。在体外评估了它们对肿瘤细胞系 MCF-7、MDA-MB-231、HepG2 和 A549 以及正常 HUVEC 系的细胞毒性活性。化合物 1-8 对肿瘤细胞系表现出不同水平的抑制活性。
