Quassinoids as inhibitors of Epstein-Barr virus early antigen activation.

作者信息

Kubota K, Fukamiya N, Tokuda H, Nishino H, Tagahara K, Lee K H, Okano M

机构信息

Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts, Hiroshima University, Kagamiyama, Japan.

出版信息

Cancer Lett. 1997 Feb 26;113(1-2):165-8. doi: 10.1016/s0304-3835(97)04607-7.

DOI:10.1016/s0304-3835(97)04607-7

PMID:9065817

Abstract

Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for 14 quassinoids isolated from Ailanthus altissima. Some quassinoids, including ailantinol B, ailantinol C, ailanthone, and shinjulactone A, showed moderate activity at a molar ratio of 1:100 (TPA/quassinoids), and the results led to the elucidation of structure-activity relationships.

摘要