Siddiqui Bina Shaheen, Afshan Farhana, Gulzar Tahsin, Sultana Razia, Naqvi Syed Naeemul-Hassan, Tariq Rajput Mohammad
H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan.
Chem Pharm Bull (Tokyo). 2003 Apr;51(4):415-7. doi: 10.1248/cpb.51.415.
A new tetranortriterpenoid, meliatetraolenone [24,25,26,27-tetranor-apotirucalla-(apoeupha)-6alpha-O-methyl, 7alpha-senecioyl(7-deacetyl)-11alpha,12alpha,21,23-tetrahydroxy-21,23-epoxy-2,14,20(22)-trien-1,16-dione] (1) was isolated from the methanolic extract of fresh leaves of Azadirachta indica along with the known compound odoratone (3) which was hitherto unreported from this source. Their structures have been elucidated by spectral studies including 2D NMR. The insecticidal activities of 1 as well as those of odoratone (3) are reported. 1 and odoratone both showed mortality on fourth instar larvae of mosquitoes (Anopheles stephensi) with LC(50) values of 16 and 154 ppm, respectively.
从印楝新鲜叶片的甲醇提取物中分离出一种新的四降三萜类化合物，印楝四降豆甾烯酮24,25,26,27-四降-去甲葫芦素-(去甲大戟)-6α-O-甲基，7α-千里光酰基(7-去乙酰基)-11α,12α,21,23-四羟基-21,23-环氧-2,14,20(22)-三烯-1,16-二酮，以及已知化合物奥多酮(3)，该化合物此前未从该来源报道过。它们的结构已通过包括二维核磁共振在内的光谱研究得以阐明。报道了化合物1以及奥多酮(3)的杀虫活性。化合物1和奥多酮对四龄期蚊虫幼虫(斯氏按蚊)均显示出致死作用，其半数致死浓度(LC50)值分别为16 ppm和154 ppm。
