Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania.
Department of Fundamental, Prophylactic and Clinical Sciences, Faculty of Medicine, University Transilvania Braşov, 500019 Brasov, Romania.
Int J Mol Sci. 2018 Dec 5;19(12):3898. doi: 10.3390/ijms19123898.
In recent years, a wide range of studies have pointed out the importance of nutraceuticals as reservoirs of therapeutic compounds for several diseases, including cancer. This study is centered on the role of some nutraceuticals as anticancer agents and on their efficiency in the oncological gynecological field. Gynecological cancers include cervical, ovarian, and breast neoplasia and these are the major causes of morbidity and mortality in the female population. Cervical neoplasia affects sexually active women aged between 30 and 40 years and is considered the second leading cause of death for women worldwide. Epidemiological studies have shown a strong association of this cancer with human papilloma virus (HPV) infection, independent of any others risk factors. Ovarian cancer represents about 4% of all women's cancers and breast neoplasia registers 52.8 new cases per 100,000 women annually. Since ancient times, herbal therapies have shown a wide range of beneficial effects and a high potential for safeguarding human health. (Neem) is a medicinal plant of Indian origin, a tree with more of 140 isolated compounds and at least 35 biologically active principles that have shown an important influence as tumor suppressors by interfering with the carcinogenesis process. Used for centuries in Asia as a natural remedy for cancer, neem compounds present in bark, leaves, flowers, and seed oil have been shown to possess properties such as chemopreventive capacity, apoptotic activities, immunomodulatory effects, and induction of p53-independent apoptosis. The current study is a systematic literature review based on the anticarcinogenic potential of neem compounds in gynecological cancers.
近年来，大量研究指出了营养保健品作为治疗多种疾病（包括癌症）化合物的储备库的重要性。本研究集中于某些营养保健品作为抗癌剂的作用及其在妇科肿瘤学领域的效率。妇科癌症包括宫颈癌、卵巢癌和乳腺癌，这些是女性发病和死亡的主要原因。宫颈癌影响 30 至 40 岁之间有性生活的女性，是全球女性死亡的第二大主要原因。流行病学研究表明，这种癌症与人类乳头瘤病毒（HPV）感染密切相关，与任何其他危险因素无关。卵巢癌约占所有女性癌症的 4%，乳腺癌每年每 10 万女性中有 52.8 例新发病例。自古以来，草药疗法就表现出广泛的有益效果和高度保护人类健康的潜力。（印度楝树）是一种源自印度的药用植物，是一种有 140 多种分离化合物的树，至少有 35 种生物活性物质，通过干扰致癌过程显示出作为肿瘤抑制剂的重要影响。在亚洲，印度楝树被几个世纪以来用作癌症的天然疗法，其树皮、叶子、花朵和种子油中的化合物已被证明具有化学预防能力、细胞凋亡活性、免疫调节作用和诱导 p53 非依赖性细胞凋亡。本研究是基于印度楝树化合物在妇科癌症中的抗癌潜力的系统文献综述。
