Wu Xiaodong, Cooper Richard S, Boerwinkle Eric, Turner Stephen T, Hunt Steve, Myers Richard, Olshen Richard A, Curb David, Zhu Xiaofeng, Kan Donghui, Luke Amy
Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA.
Eur J Hum Genet. 2003 Mar;11(3):271-4. doi: 10.1038/sj.ejhg.5200952.
A combined analysis of genome scans was performed for adult height in the NHLBI Family Blood Pressure Program. Height data were available on 6752 individuals. Linkage analysis was performed first separately for each of the eight ethnic groups in the four networks using the variance component method. To increase the power to detect the common genetic components affecting height for all the individuals, a linkage analysis was performed subsequently for the combined data set by pooling the average allele-sharing IBD () for all groups. By combining the data, we replicated evidence for a QTL influencing adult height on chromosome 7 (7q31) (LOD=2.46), which has been reported in two previous studies. Suggestive linkage (LOD>1) was found in another six regions in our combined analysis. Evidence for linkage for two of these regions (2p12, 20p11) has also been reported previously.
在 NHLBI 家族血压项目中，对成人身高进行了全基因组扫描的联合分析。共有 6752 名个体的身高数据。首先使用方差成分法对四个网络中的八个种族群体分别进行连锁分析。为了提高检测影响所有个体身高的常见遗传成分的能力，随后通过汇总所有群体的平均等位基因共享 IBD（）对合并数据集进行连锁分析。通过合并数据，我们复制了之前两项研究中报道的位于 7 号染色体（7q31）上影响成人身高的一个数量性状基因座的证据（LOD = 2.46）。在我们的联合分析中，在另外六个区域发现了提示性连锁（LOD>1）。之前也有报道称其中两个区域（2p12、20p11）存在连锁证据。
