Yang Yong, Xing Lei
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305-5304, USA.
Med Phys. 2003 Mar;30(3):433-41. doi: 10.1118/1.1543150.
Intensity modulated radiation therapy (IMRT) is an advanced form of radiation therapy and promises to improve dose conformation while reducing the irradiation to the sensitive structures. The modality is, however, more complicated than conventional treatment and requires much more stringent quality assurance (QA) to ensure what has been planned can be achieved accurately. One of the main QA tasks is the assurance of positioning accuracy of multileaf collimator (MLC) leaves during IMRT delivery. Currently, the routine quality assurance of MLC in most clinics isbeing done using radiographic films with specially designed MLC leaf sequences. Besides being time consuming, the results of film measurements are difficult to quantify and interpret. In this work, we propose a new and effective technique for routine MLC leaf positioning QA. The technique utilizes the fact that, when a finite-sized detector is placed under a leaf, the relative output of the detector will depend on the relative fractional volume irradiated. A small error in leaf positioning would change the fractional volume irradiated and lead to a deviation of the relative output from the normal reading. For a given MLC and detector system, the relation between the relative output and the leaf displacement can be easily established through experimental measurements and used subsequently as a quantitative means for detecting possible leaf positional errors. The method was tested using a linear accelerator with an 80-leaf MLC. Three different locations, including two locations on central plane (X1 = X2 = 0) and one point on an off-central plane location (X1 = -7.5, X = 7.5), were studied. Our results indicated that the method could accurately detect a leaf positional change of approximately 0.1 mm. The method was also used to monitor the stability of MLC leaf positioning for five consecutive weeks. In this test, we intentionally introduced two positional errors in the testing MLC leaf sequences: -0.2 mm and 1.2 mm. The technique was found to be robust and could detect the positional inaccuracy in each week's test. The influence of other possible error sources, including the ion chamber placement, jaw settings, gantry and collimator angle read-outs, and the positioning errors of the adjacent leaves, on detection accuracy were also investigated. The principle of our method is independent of the types of the MLC and the detector and may have significant practical implications in facilitating routine MLC QA for IMRT delivery.
调强放射治疗(IMRT)是放射治疗的一种先进形式,有望在减少对敏感结构照射的同时改善剂量适形度。然而,这种治疗方式比传统治疗更为复杂,需要更严格的质量保证(QA)来确保所计划的治疗能够准确实现。主要的QA任务之一是在IMRT治疗过程中确保多叶准直器(MLC)叶片的定位精度。目前,大多数诊所对MLC的常规质量保证是使用带有专门设计的MLC叶片序列的射线照相胶片来进行的。除了耗时之外,胶片测量的结果也难以量化和解释。在这项工作中,我们提出了一种用于MLC叶片定位常规QA的新的有效技术。该技术利用了这样一个事实,即当一个有限尺寸的探测器放置在一片叶片下方时,探测器的相对输出将取决于被照射的相对分数体积。叶片定位的微小误差会改变被照射的分数体积,并导致相对输出偏离正常读数。对于给定的MLC和探测器系统,相对输出与叶片位移之间的关系可以通过实验测量轻松建立,并随后用作检测可能的叶片位置误差的定量手段。该方法使用配备80叶MLC的直线加速器进行了测试。研究了三个不同的位置,包括中心平面上的两个位置(X1 = X2 = 0)和一个离中心平面位置上的点(X1 = -7.5,X = 7.5)。我们的结果表明,该方法能够准确检测到约0.1毫米的叶片位置变化。该方法还用于连续五周监测MLC叶片定位的稳定性。在该测试中,我们在测试的MLC叶片序列中故意引入了两个位置误差:-0.2毫米和1.2毫米。结果发现该技术具有鲁棒性,能够在每周的测试中检测到位置不准确情况。还研究了其他可能的误差源,包括电离室放置、准直器设置、机架和准直器角度读数以及相邻叶片的定位误差对检测精度的影响。我们方法的原理与MLC和探测器的类型无关,可能对促进IMRT治疗中MLC的常规QA具有重要的实际意义。