Crowell-Davis Sharon L, Seibert Lynne M, Sung Wailani, Parthasarathy Valli, Curtis Terry M
Department of Anatomy and Radiology College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
J Am Vet Med Assoc. 2003 Mar 15;222(6):744-8. doi: 10.2460/javma.2003.222.744.
To evaluate use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs.
Prospective open clinical trial.
40 dogs with storm phobia.
Dogs received clomipramine at a dosage of 2 mg/kg (0.9 mg/lb), PO, every 12 hours for 3 months; then 1 mg/kg (0.45 mg/lb), PO, every 12 hours for 2 weeks; then 0.5 mg/kg (0.23 mg/lb), PO, every 12 hours for 2 weeks. Alprazolam was given at a dosage of 0.02 mg/kg (0.009 mg/lb), PO, as needed 1 hour before anticipated storms and every 4 hours as needed. Desensitization and counter-conditioning were conducted at home by the caregiver with an audio simulation of storm sounds that had induced a fear response during evaluation.
30 of the 32 dogs that completed the study had a degree of improvement, as measured by caregivers' global assessment. Two caregivers considered the storm phobia to be resolved. Panting, pacing, trembling, remaining near the caregiver, hiding, excessive salivation, destructiveness, excessive vocalization, self-trauma, and inappropriate elimination all decreased significantly during treatment. Improvement was greater during true storms (rain, thunder, and lightning) than during rain only. Response to audio simulation did not change during treatment. Four months after the study, improvement was maintained.
The combination of clomipramine, alprazolam, and behavior modification can be effective in decreasing or eliminating storm phobia. Improvement could not be evaluated by use of audio simulation of a storm.
评估氯米帕明、阿普唑仑及行为矫正疗法对犬类暴风雨恐惧症的治疗效果。
前瞻性开放临床试验。
40只患有暴风雨恐惧症的犬。
犬每12小时口服一次氯米帕明，剂量为2毫克/千克（0.9毫克/磅），持续3个月；之后每12小时口服1毫克/千克（0.45毫克/磅），持续2周；然后每12小时口服0.5毫克/千克（0.23毫克/磅），持续2周。根据需要，在预计暴风雨来临前1小时及之后每4小时，按0.02毫克/千克（0.009毫克/磅）的剂量口服阿普唑仑。护理人员在家中通过播放评估期间诱发恐惧反应的暴风雨声音的音频模拟进行脱敏和对抗条件作用训练。
在完成研究的32只犬中，30只有所改善，这是根据护理人员的总体评估得出的。两名护理人员认为暴风雨恐惧症已消除。在治疗期间，气喘、踱步、颤抖、靠近护理人员、躲藏、过度流涎、破坏行为、过度吠叫、自我伤害及不适当排尿等情况均显著减少。在真正的暴风雨（降雨、打雷和闪电）期间的改善程度大于仅降雨期间。治疗期间对音频模拟的反应没有变化。研究结束四个月后，改善情况得以维持。
氯米帕明、阿普唑仑及行为矫正疗法联合使用可有效减轻或消除暴风雨恐惧症。无法通过暴风雨的音频模拟来评估改善情况。
