Possible role of histamine receptors in cardiovascular responses to 5-hydroxytryptamine in the chicken.

Mepyramine (a selective H1-histamine receptor antagonist) and burimamide (a selective H2-receptor antagonist) specifically and equally modify the systemic hypotensive responses to both serotonin and histamine. Results suggest that both H1- and H2-histamine receptors in part mediate systemic arterial depressor and venous pressor responses to 5-HT in the domestic chicken.