Liu Dexi, Ren Tan, Gao Xiang
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Curr Med Chem. 2003 Jul;10(14):1307-15. doi: 10.2174/0929867033457386.
This review focuses on the recent developments in study of cationic lipids as carriers for DNA delivery. Emphasis is placed on a class of compounds as exemplifies by their similarity in structures and transfection activities. The technical aspects are also reviewed on how to prepare DNA-lipid complexes and to perform transfection. A brief discussion of the current views on the mechanism of cationic lipid-mediated DNA transfer is intended to provide new prospects for future developments and further improvement of the current systems.
本综述聚焦于阳离子脂质作为DNA递送载体研究的最新进展。重点关注一类化合物，它们在结构和转染活性上具有相似性。还综述了制备DNA-脂质复合物及进行转染的技术方面。对阳离子脂质介导的DNA转移机制的当前观点进行简要讨论，旨在为未来发展和当前系统的进一步改进提供新的前景。
