Schulze Katja, McDonald Colm, Frangou Sophia, Sham Pak, Grech Anton, Toulopoulou Timothea, Walshe Muriel, Sharma Tonmoy, Sigmundsson Thordur, Taylor Mark, Murray Robin M
Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom.
Biol Psychiatry. 2003 Apr 1;53(7):562-70. doi: 10.1016/s0006-3223(02)01910-8.
There is evidence for hippocampal volume loss in schizophrenia, but the etiology of this remains unclear. The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia.
Hippocampal volumes were obtained using stereological methods from magnetic resonance scans performed on 35 schizophrenic probands from multiply affected families and 63 of their unaffected relatives, as well as 31 schizophrenic probands from families with no other affected members, 33 of their unaffected relatives, and 68 control subjects.
Probands with schizophrenia, regardless of family history, had significant volume reduction of the left hippocampus. Hippocampal volume was not significantly reduced in either group of relatives. Obstetric complications were associated with left hippocampal volume reduction.
We failed to find evidence that hippocampal volume loss is associated with familial liability to schizophrenia but have confirmed the association between hippocampal volume reduction and exposure to obstetric complications.
有证据表明精神分裂症患者存在海马体体积减小的情况，但其病因尚不清楚。我们研究的目的是评估家族易感性和产科并发症对精神分裂症患者海马体体积减小的影响。
采用体视学方法，对来自多个患病家庭的35名精神分裂症先证者及其63名未患病亲属、来自无其他患病成员家庭的31名精神分裂症先证者及其33名未患病亲属以及68名对照者进行磁共振扫描，获取海马体体积。
无论家族史如何，精神分裂症先证者的左侧海马体体积均显著减小。两组亲属的海马体体积均未显著减小。产科并发症与左侧海马体体积减小有关。
我们未能找到证据表明海马体体积减小与精神分裂症的家族易感性有关，但证实了海马体体积减小与产科并发症暴露之间的关联。
