Blackwood L, Dobson J M
Queen's Veterinary School Hospital, University of Cambridge, England.
J Am Vet Med Assoc. 1996 Jul 1;209(1):98-102.
To evaluate response to radiotherapy in dogs with oral malignant melanomas.
Clinical trial.
36 dogs with histologically confirmed oral malignant melanomas.
The prescribed radiation dose was 36 Gy given in 4 fractions of 9 Gy at 7-day intervals. The primary radiation source was a linear accelerator.
In 25 of 36 dogs, complete remission was achieved, and in 9 dogs, partial remission was achieved. Recurrence of the primary tumor was the cause of euthanasia of 4 dogs. Twenty-one dogs were euthanatized because of metastasis.
Radiotherapy was an effective palliative treatment for the primary tumor in dogs with oral malignant melanomas. However, rapid development of metastatic disease remained a major challenge.
评估口腔恶性黑色素瘤犬对放疗的反应。
临床试验。
36只经组织学确诊为口腔恶性黑色素瘤的犬。
规定的放射剂量为36 Gy，分4次给予，每次9 Gy，间隔7天。主要放射源为直线加速器。
36只犬中有25只完全缓解，9只部分缓解。4只犬因原发性肿瘤复发而实施安乐死。21只犬因转移而实施安乐死。
放疗是口腔恶性黑色素瘤犬原发性肿瘤的一种有效姑息治疗方法。然而，转移性疾病的快速发展仍然是一个主要挑战。
