白血病细胞对人骨髓细胞体外集落形成的影响 Ⅱ. 白血病细胞提取物的抑制作用
Influence of leukaemic cells on the colony formation of human bone marrow cells in vitro II. Suppressive effects of leukaemic cell extracts.
作者信息
Chiyoda S, Mizoguchi H, Asano S, Takaku F, Miura Y
出版信息
Br J Cancer. 1976 Apr;33(4):379-84. doi: 10.1038/bjc.1976.62.
The influence of leukaemic cells on the colony formation of human bone marrow cells was studied in vitro as an extension of our previous work (Chiyoda et al., 1975). An extract of leukaemic bone marrow cells significantly suppressed colony forming ability of the normal bone marrow cells, whereas an extract of normal bone marrow cells did not suppress it except in two cases. The suppressive effect of normal bone marrow cells, however, was obviously less intense than that of leukaemic cells. This suppressive effect was dose dependent and was fairly stable to heat treatment. These results suggest that leukaemic bone marrow cells contain factor(s) which suppress normal colony formation.
作为我们之前工作（千叶田等人，1975年）的延伸，我们在体外研究了白血病细胞对人骨髓细胞集落形成的影响。白血病骨髓细胞提取物显著抑制正常骨髓细胞的集落形成能力，而正常骨髓细胞提取物除两例情况外未表现出抑制作用。然而，正常骨髓细胞的抑制作用明显弱于白血病细胞。这种抑制作用呈剂量依赖性，并且对热处理相当稳定。这些结果表明，白血病骨髓细胞含有抑制正常集落形成的因子。
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