Galbraith P R, Cooke L J, Baker F L
Can Med Assoc J. 1979 Mar 3;120(5):545-55.
The concept that polymorphonuclear leukocytes, or neutrophils, play a role in feedback control of granulopoiesis has been supported by the finding in bone marrow culture studies that mature neutrophils inhibited formation of granulocytic colonies. The study described in this paper was done to investigate the mechanisms involved. With the use of a modified assay it was found that mature neutrophils released factors that reduced the proliferation of colony-forming cells in cultures stimulated by cell-free colony-stimulating factor. In myeloproliferative and myelodysplastic disorders the amount of inhibitor released by the neutrophils varied greatly. Leukemic blast cells also released inhibitor, and in some cases the amount released per cell was greater than the amount released from normal mature neutrophils. The inhibitory factors released from the neutrophils differed from those previously described in the literature in terms of mode of action and apparent molecular size.
多形核白细胞，即中性粒细胞，在粒细胞生成的反馈控制中发挥作用这一概念，已得到骨髓培养研究结果的支持，该研究发现成熟中性粒细胞会抑制粒细胞集落的形成。本文所述的研究旨在探究其中涉及的机制。通过使用改良检测方法发现，成熟中性粒细胞会释放一些因子，这些因子会降低无细胞集落刺激因子刺激的培养物中集落形成细胞的增殖。在骨髓增殖性疾病和骨髓增生异常综合征中，中性粒细胞释放的抑制剂数量差异很大。白血病原始细胞也会释放抑制剂，在某些情况下，每个细胞释放的量大于正常成熟中性粒细胞释放的量。中性粒细胞释放的抑制因子在作用方式和表观分子大小方面与文献中先前描述的不同。
