Kirby J D, Munro D D
Br J Dermatol. 1976 Mar;94 suppl 12:111-9. doi: 10.1111/j.1365-2133.1976.tb02279.x.
A ratchet-controlled micrometer screw gauge has been used to measure the changes in skin thickness produced by topical corticosteroids. Measurable thinning of the mouse ear followed repeated daily application of corticosteroids. This response in the animal was used to assess the atrophic potential in a variety of standard formulations. The same compounds were applied to human skin and the changes in thickness measured. Patterns of response and the rank order of thinning obtained from the animal model were found to parallel closely the human results.
一种棘轮控制的千分尺螺旋测微器已被用于测量局部皮质类固醇引起的皮肤厚度变化。每天重复涂抹皮质类固醇后，小鼠耳朵出现了可测量的变薄现象。动物的这种反应被用来评估各种标准制剂的萎缩潜力。将相同的化合物应用于人体皮肤并测量厚度变化。发现从动物模型获得的反应模式和变薄的等级顺序与人体结果非常相似。
