Uchida Katsuhisa, Tanaka Takashi, Yamaguchi Hideyo
Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192-0395, Japan.
Microbiol Immunol. 2003;47(2):143-6. doi: 10.1111/j.1348-0421.2003.tb02797.x.
We examined the therapeutic effect of a 1% cream preparation of NND-502, a novel topical antifungal agent, in a guinea pig tinea pedis model produced by infecting the plantar skin of guinea pigs with Trichophyton mentagrophytes. Animals developing tinea pedis were divided into two groups: an untreated control group and a treated group. In the latter group, after confirming infection had been established, the infected animals were topically treated with the NND-502 cream once daily for one week. The animals were reared in a clean environment free from exposure to exogenous dermatophytes. At one week (5 weeks post-infection), 6 weeks (10 weeks post-infection) and 16 weeks (20 weeks post-infection) after completion of the treatment, plantar skin samples were taken from a certain number of both groups of animals. The results demonstrated that all of the animals in the untreated control group and none of those in the treated group were culture-positive in this animal model of tinea pedis. The topical treatment with NND-502 achieved a mycological cure. Thus NND-502 can be considered a promising candidate as a new anti-dermatophytic agent for topical use.
我们在豚鼠足癣模型中研究了新型外用抗真菌剂NND - 502的1%乳膏制剂的治疗效果，该模型通过用须癣毛癣菌感染豚鼠足底皮肤而建立。发生足癣的动物被分为两组：未治疗的对照组和治疗组。在后者组中，确认感染确立后，感染的动物每天外用NND - 502乳膏一次，持续一周。动物饲养在无外源性皮肤癣菌暴露的清洁环境中。治疗结束后1周（感染后5周）、6周（感染后10周）和16周（感染后20周），从两组动物中各取一定数量的足底皮肤样本。结果表明，在该豚鼠足癣动物模型中，未治疗的对照组所有动物培养均为阳性，而治疗组无一例培养阳性。外用NND - 502实现了真菌学治愈。因此，NND - 502可被认为是一种有前景的新型外用抗皮肤癣菌剂候选药物。
