Itoyama T, Uchida K, Yamaguchi H, Fujita S
Teikyo University Institute of Medical Mycology, Tokyo, Japan.
J Antimicrob Chemother. 1997 Sep;40(3):441-4. doi: 10.1093/jac/40.3.441.
The therapeutic efficacy of omoconazole nitrate was investigated in an experimental tinea pedis model produced by topical inoculation with Trichophyton mentagrophytes in guinea-pigs, which is pathologically similar to naturally infected tinea pedis in humans. Treatment with omoconazole nitrate cream was started on week 2 postinfection and continued for 3 or 4 weeks. Once-a-day application of 1% omoconazole nitrate to the site of infection exhibited an excellent therapeutic efficacy, and was superior to 1% bifonazole cream in culture result. This result suggests that omoconazole nitrate has a potential usefulness for the treatment of tinea pedis in humans.
在豚鼠足癣实验模型中研究了硝酸奥莫康唑的治疗效果，该模型通过局部接种须癣毛癣菌产生，在病理上与人类自然感染的足癣相似。感染后第2周开始用硝酸奥莫康唑乳膏治疗，并持续3或4周。每天一次在感染部位涂抹1%硝酸奥莫康唑显示出优异的治疗效果，在培养结果方面优于1%联苯苄唑乳膏。该结果表明硝酸奥莫康唑在治疗人类足癣方面具有潜在的应用价值。
