Müller-Berghaus G, Bohn E, Höbel W
Br J Haematol. 1976 Jun;33(2):213-20. doi: 10.1111/j.1365-2141.1976.tb03532.x.
The importance of granulocytes and/or platelets in endotoxin-induced generalized intravascular coagulation was studied as well as thrombocytopenic rabbits. Neutropenia and thrombocytopenia were induced by oral administration of busulphan. Generalized intravascular coagulation, as indicated by renal glomerular microclot formation, was initiated by two intravenous injections of endotoxin. Granulocyte counts before the second injection of endotoxin were most significantly related to activation of intravascular coagulation whereas platelet counts either before the first or second injection of endotoxin were not definitely related to the activation process. Renal glomerular microclots occurred in rabbits after two injections of endotoxin even when the platelet counts were between 500 and 5000/mul. These experiments indicated that granulocytes but not platelets are essential to the activation of endotoxin-induced intravascular coagulation.
研究了粒细胞和/或血小板在内毒素诱导的全身性血管内凝血中的重要性，同时也对血小板减少的兔子进行了研究。通过口服白消安诱导中性粒细胞减少和血小板减少。通过两次静脉注射内毒素引发全身性血管内凝血，以肾小球微血栓形成为指标。第二次注射内毒素前的粒细胞计数与血管内凝血的激活最为显著相关，而第一次或第二次注射内毒素前的血小板计数与激活过程并无明确关联。即使血小板计数在500至5000/μl之间，两次注射内毒素后的兔子仍会出现肾小球微血栓。这些实验表明，粒细胞而非血小板是内毒素诱导的血管内凝血激活所必需的。
