一名患有慢性肉芽肿病的患者发生烟曲霉引起的股骨骨髓炎。
Femoral osteomyelitis due to Aspergillus nidulans in a patient with chronic granulomatous disease.
作者信息
Dotis J, Panagopoulou P, Filioti J, Winn R, Toptsis C, Panteliadis C, Roilides E
机构信息
Third Dept. of Pediatrics, Aristotle University of Thessaloniki, Hippokration Hospital, Konstantinoupoleos 49, GR-54642 Thessaloniki, Greece.
出版信息
Infection. 2003 Mar;31(2):121-4. doi: 10.1007/s15010-002-2167-1.
13 cases of osteomyelitis caused by Aspergillus nidulans have been previously reported in patients with chronic granulomatous disease (CGD). All of them have been associated with simultaneous pulmonary infection and have had an extremely poor outcome. We report an unusual case of femoral osteomyelitis due to A. nidulans in a 16-year-old male with CGD, without pulmonary involvement. Treatment with liposomal amphotericin B and granulocyte colony-stimulating factor as well as extensive surgical debridement followed by prolonged treatment with itraconazole resulted in an excellent clinical response.
先前已有报道称，13例由构巢曲霉引起的骨髓炎发生在慢性肉芽肿病（CGD）患者中。所有这些病例都伴有同时发生的肺部感染，且预后极差。我们报告了一例罕见病例，一名16岁患有CGD的男性因构巢曲霉导致股骨骨髓炎，未累及肺部。采用脂质体两性霉素B和粒细胞集落刺激因子治疗，以及广泛的外科清创术，随后长期使用伊曲康唑治疗，取得了良好的临床疗效。
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