Karagezian K G, Ovsepian L M, Dadaian M A, Adonts K G
Vopr Med Khim. 1978 Jan-Feb;24(1):73-6.
Peroxidation of lipids and alteration in antioxidative activity were studied in normal state and in experimental pancreatitis within 1, 3, 7, 14 and 30 days after the operation. Experimental pancreatitis was accompanied by increase in content of lipid peroxides and by decrease in antioxidative activity of lipids extracted from liver tissue. Administration of thiosulfate decreased slightly the lipid peroxides content and increased the level of antioxidants in pancreatitis. The data obtained suggest that thiosulfate is effective inhibitor of free radical oxidation; it may be used as therapeutic drug in acute pancreatitis.
在正常状态以及术后1、3、7、14和30天的实验性胰腺炎状态下，研究了脂质过氧化和抗氧化活性的变化。实验性胰腺炎伴随着脂质过氧化物含量的增加以及从肝组织中提取的脂质抗氧化活性的降低。给予硫代硫酸盐可使胰腺炎中的脂质过氧化物含量略有降低，并提高抗氧化剂水平。所得数据表明，硫代硫酸盐是自由基氧化的有效抑制剂；它可用作急性胰腺炎的治疗药物。
