Dijkstra S, Klok M, van Hoogenhuyze D, Sauerwein H P, Berghout A
Department of Internal Medicine, Rijnmond Zuid Medical Centre, Groene Hilledijk 315, 3075 EA Rotterdam, The Netherlands.
Neth J Med. 2002 Dec;60(11):434-7.
To study the prevalence of ischaemic heart disease in Turkish and Surinam-Asian migrants with type 2 diabetes mellitus in the Netherlands as compared with Europeans.
In a consecutive case-control study, 59 Turkish and 62 Surinam-Asian patients were compared with 185 Europeans referred to a diabetes clinic for treatment of type 2 diabetes in the period 1992 to 1998. Main outcome measures were ischaemic heart disease and its associated risk factors.
The prevalence of ischaemic heart disease was lower (9%) in the Turks (p < 0.02), but higher (29%) in the Surinam-Asians compared with the Europeans (23%). The Turks (52 +/- 10 years) and Surinam-Asians (46 +/- 12 years) were younger than the Europeans (64 +/- 11 years, p < 0.001). Body mass index was 32 +/- 5 (p < 0.001) in the Turks, 27 +/- 5 in the Surinam-Asians (p < 0.05) and 29 +/- 5 in the Europeans. Turkish patients smoked less (23%, p < 0.05) and used less alcohol (4%, p < 0.05) than the Europeans. Proteinuria was found in 24% of the Turks (p < 0.05), 37% of the Surinam-Asians (NS) and 46% of the Europeans. In univariate analysis ischaemic heart disease was related to Turkish origin, OR 0.34 (0.14-0.83) p < 0.02, to Surinam-Asian origin, OR 1.84 (1.00-3.38) p = 0.05, and smoking, OR 1.78 (1.18-2.68) p < 0.01. Other variables were not related to ischaemic heart disease. Multivariate analysis in a model with ethnicity and smoking showed significant relations between ischaemic heart disease and Turkish ethnicity, OR 0.19 (0.06-0.65) p = 0.007, Surinam-Asian origin, OR 2.77 (1.45-5.28) p = 0.002, and smoking, OR 1.79 (1.20-2.66) p = 0.004.
Type 2 diabetes mellitus in different ethnic groups results in a significant difference in incidence of ischaemic heart disease. The most remarkable finding is a low incidence of ischaemic heart disease in the Turkish patients with type 2 diabetes, independent of smoking. The high prevalence of ischaemic heart disease in young migrant Asians with diabetes is confirmed.
研究在荷兰的土耳其裔和苏里南裔亚洲 2 型糖尿病移民中缺血性心脏病的患病率，并与欧洲人进行比较。
在一项连续病例对照研究中，将 59 名土耳其患者和 62 名苏里南裔亚洲患者与 185 名 1992 年至 1998 年期间因 2 型糖尿病到糖尿病诊所就诊的欧洲人进行比较。主要观察指标为缺血性心脏病及其相关危险因素。
与欧洲人（23%）相比，土耳其人缺血性心脏病患病率较低（9%）（p<0.02），而苏里南裔亚洲人患病率较高（29%）。土耳其人（52±10 岁）和苏里南裔亚洲人（46±12 岁）比欧洲人年轻（64±11 岁，p<0.001）。土耳其人的体重指数为 32±5（p<0.001），苏里南裔亚洲人为 27±5（p<0.05），欧洲人为 29±5。土耳其患者吸烟较少（23%，p<0.05），饮酒也较少（4%，p<0.05）。24%的土耳其人（p<0.05）、37%的苏里南裔亚洲人（无显著差异）和 46%的欧洲人存在蛋白尿。单因素分析显示，缺血性心脏病与土耳其裔有关，比值比为 0.34（0.14 - 0.83），p<0.02；与苏里南裔亚洲人有关，比值比为 1.84（1.00 - 3.38），p = 0.05；与吸烟有关，比值比为 1.78（1.18 - 2.68），p<0.01。其他变量与缺血性心脏病无关。在一个包含种族和吸烟因素的模型中进行多因素分析显示，缺血性心脏病与土耳其种族显著相关，比值比为 0.19（0.06 - 0.65），p = 0.007；与苏里南裔亚洲人有关，比值比为 2.77（1.45 - 5.28），p = 0.002；与吸烟有关，比值比为 1.79（1.20 - 2.66），p = 0.004。
不同种族的 2 型糖尿病导致缺血性心脏病发病率存在显著差异。最显著的发现是 2 型糖尿病土耳其患者中缺血性心脏病发病率较低，且与吸烟无关。糖尿病年轻亚洲移民中缺血性心脏病的高患病率得到证实。
