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叶酸反应性神经病:10例报告。

Folate-responsive neuropathy: report of 10 cases.

作者信息

Manzoor M, Runcie J

出版信息

Br Med J. 1976 May 15;1(6019):1176-8. doi: 10.1136/bmj.1.6019.1176.

Abstract

Ten patients with severe neurological disease that was clinically indistinguishable from subacute combined degeneration of the spinal cord were found to have normal serum vitamin B12 levels. All were folate deficient. Specific folate treatment led to significant reversal of the neuropathy. These findings indicate the need to review orthodox concepts of the role of folic acid in maintaining the integrity of the nervous system.

摘要

十名患有严重神经系统疾病的患者,其临床表现与脊髓亚急性联合变性无法区分,结果发现他们的血清维生素B12水平正常。所有人均缺乏叶酸。特定的叶酸治疗使神经病变显著逆转。这些发现表明有必要重新审视叶酸在维持神经系统完整性方面作用的传统观念。

相似文献

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Folate-responsive neuropathy: report of 10 cases.叶酸反应性神经病:10例报告。
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[Folate deficiency and neurologic disorders].
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本文引用的文献

3
Lactobacillus casei C.S.F. folate activity.干酪乳杆菌C.S.F.的叶酸活性。
Br Med J. 1967 Sep 30;3(5569):834-6. doi: 10.1136/bmj.3.5569.834.
5
Congenital defects in folate utilization.叶酸利用方面的先天性缺陷。
Am J Med. 1970 May;48(5):594-8. doi: 10.1016/0002-9343(70)90009-4.
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Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy.
Lancet. 1968 Mar 16;1(7542):563-5. doi: 10.1016/s0140-6736(68)92832-8.
8
Reversible central nervous system dysfunction in folate deficiency.
J Neurol Sci. 1975 May;25(1):93-8. doi: 10.1016/0022-510x(75)90189-6.

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