甲基多巴对催乳素和生长激素的影响。
Effects of methyldopa on prolactin and growth hormone.
作者信息
Steiner J, Cassar J, Mashiter K, Dawes I, Fraser T R, Breckenridge A
出版信息
Br Med J. 1976 May 15;1(6019):1186-8. doi: 10.1136/bmj.1.6019.1186.
Abstract
The effects of administration of methyldopa on serum prolactin and growth hormone (GH) concentrations in hypertensive patients were studied. Single doses of methyldopa (750 or 1000 mg) significantly increased serum prolactin levels, peak concentrations occurring four to six hours after drug administrations. Long-term methyldopa treatment was associated with threefold to fourfold increases in basal prolactin levels compared with those in normal subjects. In patients treated with methyldopa for two to three weeks the GH response to insulin hypoglycaemia was significantly greater than in normal subjects and untreated hypertensive patients. In contrast, patients treated for prolonged periods (mean 13-4 months) had a GH reponse indistinguishable from normal.
摘要
研究了甲基多巴给药对高血压患者血清催乳素和生长激素（GH）浓度的影响。单剂量甲基多巴（750或1000毫克）可显著提高血清催乳素水平，给药后4至6小时出现峰值浓度。与正常受试者相比，长期使用甲基多巴治疗使基础催乳素水平增加了三到四倍。在接受甲基多巴治疗两到三周的患者中，GH对胰岛素低血糖的反应明显大于正常受试者和未治疗的高血压患者。相比之下，接受长期治疗（平均13至4个月）的患者的GH反应与正常人无异。
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