Yazici Kâzim M, Akinci Ayşen, Sütçü Ayşegül, Ozçakar Levent
Hacettepe University Faculty of Medicine, Department of Psychiatry, Ankara 06100, Turkey.
Psychiatry Res. 2003 Mar 25;117(3):271-5. doi: 10.1016/s0165-1781(03)00017-9.
This cross-sectional study investigated whether a group of unmedicated patients with major depressive disorder, single episode, had decreased bone mineral density (BMD). The BMD at the lumbar spine and proximal femur in 25 premenopausal women with major depressive disorder and 15 normal women was measured by dual-energy X-ray absorptiometry. Bone turnover markers and serum cortisol levels were also evaluated for each subject. As compared with values in the normal women, the mean BMD in the depressed women was significantly lower at the lumbar spine and at all sites of the proximal femur. There was no statistically significant difference between serum cortisol levels and bone turnover markers except for significantly higher urinary excretion of deoxypyridinoline cross-links in the patients compared with the controls. In conclusion, depressed women may have decreased BMD even at the very early stages of the illness, and this possibility should be taken into consideration in treatment.
这项横断面研究调查了一组未接受药物治疗的单相重度抑郁症患者的骨矿物质密度（BMD）是否降低。采用双能X线吸收法测量了25名绝经前重度抑郁症女性和15名正常女性的腰椎和股骨近端的骨密度。还对每个受试者的骨转换标志物和血清皮质醇水平进行了评估。与正常女性的值相比，抑郁症女性的腰椎和股骨近端所有部位的平均骨密度显著降低。除了与对照组相比患者的脱氧吡啶啉交联物尿排泄显著更高外，血清皮质醇水平和骨转换标志物之间没有统计学上的显著差异。总之，抑郁症女性即使在疾病的早期阶段也可能出现骨密度降低，在治疗中应考虑到这种可能性。
