Inamdar Maneesha S
Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, 560 064, Bangalore, India.
Dev Genes Evol. 2003 Apr;213(3):134-7. doi: 10.1007/s00427-003-0305-0. Epub 2003 Feb 15.
We have analysed the expression, during embryogenesis, of a Drosophila gene asrij (Sanskrit; asR ij = blood), which encodes a novel conserved protein with putative transmembrane domains. asrij is expressed in the pole cells, amnioserosa, trachea and hemocytes. Embryos homozygous for a chromosomal deficiency that removes asrij have no embryonic hemocytes. Expression in the blood-cell lineage precedes that of known hematopoietic transcription factors. These results suggest that Drosophila asrij functions in the hematopoietic lineage.
我们分析了果蝇基因asrij(梵语;asR ij = 血液)在胚胎发育过程中的表达情况,该基因编码一种具有推定跨膜结构域的新型保守蛋白。asrij在极细胞、羊膜浆膜、气管和血细胞中表达。因染色体缺失而纯合的胚胎,缺失了asrij基因后就没有胚胎血细胞了。在血细胞谱系中的表达先于已知造血转录因子的表达。这些结果表明,果蝇asrij在造血谱系中发挥作用。