Glassman Steven D, Alegre Gary M
University of Louisville School of Medicine, Department of Orthopaedics, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Instr Course Lect. 2003;52:579-88.
Osteoporosis has received heightened attention over the past 2 decades because of its overwhelming cost to society. It is one of the most common diseases affecting both men and women. The key to treatment is early prevention accompanied by modification of risk factors and impact-oriented exercise, optimal medical management with antiresorptive medications, and addressing the complications of this disease such as compression fractures and spinal deformities. Most osteoporotic vertebral compression fractures can be treated nonsurgically, but new techniques such as vertebroplasty and kyphoplasty are producing good early clinical results with low complication profiles. The surgical treatment of deformities such as kyphosis and scoliosis can be very challenging given the poor bone quality and propensity for instrumentation cutout. The surgical treatment of spinal stenosis in the face of deformity in these patients requires keen surgical planning and a clear identification of the source of the patient's complaints--be it the deformity, the stenosis, or both. Several advances in instrumentation, such as the use of laminar fixation (if available), multisegment fixation, limited correction of the deformity, and augmentation of pedicle screw purchase through biologic and nonbiologic fillers have been developed.
在过去20年里,骨质疏松症因其给社会带来的巨大成本而受到了更多关注。它是影响男性和女性的最常见疾病之一。治疗的关键在于早期预防,同时改变风险因素并进行有针对性的运动,采用抗吸收药物进行最佳的药物管理,以及处理该疾病的并发症,如压缩性骨折和脊柱畸形。大多数骨质疏松性椎体压缩骨折可以通过非手术治疗,但椎体成形术和后凸成形术等新技术正产生良好的早期临床效果,且并发症较少。鉴于骨质质量差和器械穿出的倾向,治疗脊柱后凸和脊柱侧弯等畸形具有很大挑战性。在这些患者中,面对畸形进行脊柱狭窄的手术治疗需要精心的手术规划,并明确识别患者的主诉来源——无论是畸形、狭窄,还是两者皆有。在器械方面已经取得了一些进展,例如使用椎板固定(如果可行)、多节段固定、有限度地矫正畸形,以及通过生物和非生物填充物增强椎弓根螺钉的把持力。