Tona Francesco, Bellotto Fabio, Laveder Francesco, Meneghin Alessia, Sinagra Gianfranco, Marcolongo Renzo
Cardiology Unit, University Hospital, Padua.
Ital Heart J. 2003 Jan;4(1):64-8.
Although idiopathic acute pericarditis is usually a self-limiting disease, in many patients it may recur over a period of months or years. Even if some evidence seems to suggest the possible role of a deranged immune reactivity in the pathogenesis of idiopathic recurrent pericarditis, the etiology of the disease is still unknown. Furthermore, while some trial data confirm the usefulness of colchicine, its medical treatment is not yet clearly established. We here report the clinical history of 2 patients with idiopathic recurrent pericarditis resistant to prednisone, colchicine and other immunosuppressive drugs, who have been successfully treated with high-dose intravenous immunoglobulins.
尽管特发性急性心包炎通常是一种自限性疾病，但在许多患者中，它可能在数月或数年的时间内复发。即使有一些证据似乎表明免疫反应紊乱在特发性复发性心包炎的发病机制中可能起作用，但该疾病的病因仍然未知。此外，虽然一些试验数据证实了秋水仙碱的有效性，但其药物治疗仍未明确确立。我们在此报告2例对泼尼松、秋水仙碱和其他免疫抑制药物耐药的特发性复发性心包炎患者的临床病史，他们已通过大剂量静脉注射免疫球蛋白成功治疗。
