Grande Ingelmo J M, Hernández Osegueda M, Kallmeyer Martín C, Barroso López J L, López Bescós L
Servicio de Cardiología, Hospital Universitario de Getafe, Madrid.
Rev Esp Cardiol. 1995 Nov;48(11):765-7.
To prove the efficacy of colchicine in the prevention of recurrences of acute pericarditis, 5 patients, age 24 to 64 years (mean 36), were treated during 18 months with 1 milligram daily. Previous treatment with steroids and/or non steroid antiinflammatory agents did not prevent 2-3 recurrences per patient, and was discontinued after entry into the study. There where no further recurrences of acute pericardial episodes during the 24 months of follow-up, and no side effects related to the treatment with colchicine were reported. We conclude that colchicine is effective in preventing the recurrences of acute idiopathic pericarditis.
为证明秋水仙碱预防急性心包炎复发的疗效，对5例年龄在24至64岁（平均36岁）的患者进行了为期18个月的治疗，每日剂量为1毫克。此前使用类固醇和/或非甾体抗炎药治疗并不能预防每位患者2至3次的复发，在进入本研究后即停用。在24个月的随访期间，未再出现急性心包炎发作，且未报告与秋水仙碱治疗相关的副作用。我们得出结论，秋水仙碱可有效预防急性特发性心包炎的复发。
