Wexler B C, McMurtry J P
Br J Exp Pathol. 1981 Apr;62(2):146-57.
Genetically obese and hypertensive rats (Obese/SHR) were subjected to sham or bilateral adrenalectomy at 4-5 weeks of age with the onset of hyperphagia. The sham-operated Obese/SHR ate voraciously and by 180 days of age males weighed 700 g and females 590 g. The adrenalectomized Obese/SHR ate much less and weighed 325 and 225 g. The systolic blood pressure of the intact Obese/SHR ranged from 160 to 170 mmHg, whereas the blood pressure of the adrenalectomized animals ranged from 108 to 110 mmHg. The thymi of the intact Obese/SHR were massive compared to those of the adrenalectomized rats. Adrenalectomy effectively reduced the hyperinsulinaemia, adiposity, hyperlipidaemia, hyperglycaemia, and elevated BUN levels of the obese rats. Several obese rats had old or new myocardial infarcts, fatty livers, giant-sized islets of Langerhans, nodular and hyperaemic adrenal glands, narrow zona glomerulosa devoid of lipid, vacuolated inner cortical zones, foci of intimal fibrinohyalin deposits in mesenteric arteries, early glomerulosclerosis, and large, rounded bladder calculi. The adrenalectomized Obese/SHR displayed none of these stigmata. It is suggested that the genetically programmed obesity and hypertension in these SHR are mediated by abnormal activity of the hypothalamic-pituitary-adrenal-gonadal axis, may be likened to Cushing's disease in the human, and is associated with accelerated ageing.
遗传性肥胖高血压大鼠（肥胖/自发性高血压大鼠）在4至5周龄出现贪食时接受假手术或双侧肾上腺切除术。接受假手术的肥胖/自发性高血压大鼠食欲旺盛，到180日龄时，雄性体重达700克，雌性体重达590克。接受肾上腺切除术的肥胖/自发性高血压大鼠食量明显减少，体重分别为325克和225克。完整的肥胖/自发性高血压大鼠收缩压在160至170毫米汞柱之间，而接受肾上腺切除术的动物血压在108至110毫米汞柱之间。与接受肾上腺切除术的大鼠相比，完整的肥胖/自发性高血压大鼠胸腺肿大。肾上腺切除术有效降低了肥胖大鼠的高胰岛素血症、肥胖、高脂血症、高血糖以及升高的血尿素氮水平。几只肥胖大鼠有陈旧性或新发性心肌梗死、脂肪肝、巨大的胰岛、结节状且充血的肾上腺、缺乏脂质的狭窄球状带、空泡化的内皮质区、肠系膜动脉内膜纤维蛋白透明质沉积灶、早期肾小球硬化以及大的圆形膀胱结石。接受肾上腺切除术的肥胖/自发性高血压大鼠未出现这些特征。提示这些自发性高血压大鼠的遗传性肥胖和高血压是由下丘脑 - 垂体 - 肾上腺 - 性腺轴的异常活动介导的，可能类似于人类的库欣病，并且与加速衰老有关。
