Desmond Renee A, Soong Seng-jaw
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Surg Clin North Am. 2003 Feb;83(1):1-29. doi: 10.1016/s0039-6109(02)00092-0.
Trends in melanoma incidence have shown an increase in thinner, less lethal tumors in recent years. The overall increases in melanoma incidence have begun to slow in Western Europe and North America. Environmental risk factors are important in the development of melanomas in individuals with high-risk phenotypes, and these people should modify their recreational and overall UV exposure. Primary prevention of melanoma and early detection are essential to reduce melanoma mortality in future years. The complex relationships between genetic factors and patterns of sun exposure, especially in childhood, are the focus of continued research.
近年来,黑色素瘤发病率的趋势显示,较薄、致死性较低的肿瘤有所增加。在西欧和北美,黑色素瘤发病率的总体增长已开始放缓。环境风险因素在具有高风险表型的个体发生黑色素瘤过程中很重要,这些人应改变其娱乐活动及总体紫外线暴露情况。黑色素瘤的一级预防和早期检测对于降低未来几年黑色素瘤死亡率至关重要。遗传因素与日晒模式之间的复杂关系,尤其是在儿童时期,仍是持续研究的重点。