Rziha H-J, Bauer B, Adam K-H, Röttgen M, Cottone R, Henkel M, Dehio C, Büttner M
Federal Research Centre for Virus Diseases of Animals, Institute of Immunology, Paul-Ehrlich-Straße 28, D-72076 Tübingen, Federal Republic of Germany.
Divison of Molecular Microbiology, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
J Gen Virol. 2003 May;84(Pt 5):1111-1116. doi: 10.1099/vir.0.18850-0.
The present study provides for the first time an extended investigation of individual genes located at the near-terminal right end of the genome of parapoxvirus bovis 1, Bovine papular stomatitis virus (BPSV) strain B177 and Orf virus (ORFV). Comparison of the respective DNA sequences of ORFV strain D1701 (9.9 kbp) and BPSV B177 (7.7 kbp) revealed a very similar organization of closely related genes transcribed in a rightward orientation. The most salient findings of this study were: (i) the absence of the ORFV-specific vascular endothelial growth factor (VEGF-E) gene in the BPSV isolate; (ii) the presence of an interleukin-10 (IL-10) orthologue; and (iii) the detection of three new genes encoding ankyrin-repeat-containing polypeptides. These results not only contribute to potential improvements of future molecular differentiation between the parapoxvirus species, but also shed new light on different pathobiologies among parapoxviruses.
本研究首次对位于牛副痘病毒1、牛丘疹性口炎病毒（BPSV）B177株和羊口疮病毒（ORFV）基因组近末端右端的单个基因进行了扩展研究。对ORFV D1701株（9.9 kbp）和BPSV B177株（7.7 kbp）各自的DNA序列进行比较后发现，以向右方向转录的密切相关基因的组织方式非常相似。本研究最显著的发现是：（i）BPSV分离株中不存在ORFV特异性血管内皮生长因子（VEGF-E）基因；（ii）存在白细胞介素-10（IL-10）同源物；（iii）检测到三个编码含锚蛋白重复序列多肽的新基因。这些结果不仅有助于未来对副痘病毒物种进行潜在的分子鉴别改进，也为副痘病毒之间不同的病理生物学提供了新的线索。
Zotero 插件