Hoffenberg P, Contreras L, Reyes V, Giglio M, Ossa P, Weitz C
Depto de Gastroenterologia, Facultad de Medicina, Universidad de Chile, Hospital San Juan de Dios.
Rev Med Chil. 1994 Jul;122(7):777-81.
histological alterations of gastric mucosa and its colonization by Helicobacter pylori are postuled to be implicated in the pathogenesis of non ulcer dyspepsia.
to study the possible relationships between histological gastritis and Helicobacter pylori in non ulcer dyspepsia symptomatology.
fifty four patients (39 females) with non ulcer dyspepsia whose ages ranged from 17 to 68 years were subjected to an upper GI endoscopy with gastric mucosa biopsy samples for histological study and microbiological identification of Helicobacter pylori. Gastrointestinal complains were blindly quantified using a scored questionnaire.
thirty one subjects (57.4%) had Helicobacter pylori in their gastric mucosa. There was acute inflammatory activity in 26 of the 31 patients with Helicobacter pylori (81%) and 15 of 23 without Helicobacter (65%). The median score of symptoms was 7 (range 2-13) in patients with Helicobacter and 6 (range 2-10) in patients without Helicobacter.
there were no significant differences in gastric mucosa acute inflammatory activity and non ulcer dyspepsia symptomatology between patients with or without Helicobacter pylori colonization of gastric mucosa.
胃黏膜的组织学改变及其被幽门螺杆菌定植被认为与非溃疡性消化不良的发病机制有关。
研究非溃疡性消化不良症状学中组织学胃炎与幽门螺杆菌之间可能的关系。
54例年龄在17至68岁之间的非溃疡性消化不良患者（39例女性）接受了上消化道内镜检查，并取胃黏膜活检样本进行组织学研究和幽门螺杆菌的微生物鉴定。使用评分问卷对胃肠道症状进行盲法量化。
31例患者（57.4%）胃黏膜中有幽门螺杆菌。31例幽门螺杆菌阳性患者中有26例（81%）存在急性炎症活动，23例幽门螺杆菌阴性患者中有15例（65%）存在急性炎症活动。幽门螺杆菌阳性患者症状的中位数评分为7分（范围2 - 13分），幽门螺杆菌阴性患者为6分（范围2 - 10分）。
胃黏膜有或无幽门螺杆菌定植的患者在胃黏膜急性炎症活动和非溃疡性消化不良症状方面无显著差异。
