Medical School, Jeonbuk National University, Jeonju, South Korea.
Department of Neurology, Jeonbuk National University Medical School and Hospital, Jeonju, South Korea.
Ann Clin Transl Neurol. 2023 Jun;10(6):933-943. doi: 10.1002/acn3.51774. Epub 2023 Apr 4.
Phosphodiesterase-5 inhibitors (PDE5Is) enhance vasodilation. We investigated the effects of PDE5I on cerebral hemodynamics during cognitive tasks using functional near-infrared spectroscopy (fNIRS).
This study used a crossover design. Twelve cognitively healthy men participants (mean age, 59 ± 3 years; range, 55-65 years) were recruited and randomly assigned to the experimental or control arm, then the experimental and control arm were exchanged after 1 week. Udenafil 100 mg was administered to participants in the experimental arm once daily for 3 days. We measured the fNIRS signal during the resting state and four cognitive tasks three times for each participant: at baseline, in the experimental arm, and in the control arm.
Behavioral data did not show a significant difference between the experimental and control arms. The fNIRS signal showed significant decreases in the experimental arm compared to the control arm during several cognitive tests: verbal fluency test (left dorsolateral prefrontal cortex, T = -3.02, p = 0.014; left frontopolar cortex, T = -4.37, p = 0.002; right dorsolateral prefrontal cortex, T = -2.59, p = 0.027), Korean-color word Stroop test (left orbitofrontal cortex, T = -3.61, p = 0.009), and social event memory test (left dorsolateral prefrontal cortex, T = -2.35, p = 0.043; left frontopolar cortex, T = -3.35, p = 0.01).
Our results showed a paradoxical effect of udenafil on cerebral hemodynamics in older adults. This contradicts our hypothesis, but it suggests that fNIRS is sensitive to changes in cerebral hemodynamics in response to PDE5Is.
磷酸二酯酶 5 抑制剂（PDE5Is）可增强血管舒张。我们使用功能近红外光谱（fNIRS）研究 PDE5I 在认知任务期间对大脑血液动力学的影响。
本研究采用交叉设计。招募了 12 名认知健康的男性参与者（平均年龄，59±3 岁；范围，55-65 岁），并随机分配到实验组或对照组，然后在 1 周后交换实验组和对照组。实验组参与者每天服用 100mg 乌地那非，连续 3 天。我们对每位参与者在静息状态和 4 项认知任务下各进行 3 次测量：基线时、实验组时和对照组时。
行为数据显示实验组和对照组之间没有显著差异。与对照组相比，实验组在多项认知测试中 fNIRS 信号明显下降：言语流畅性测试（左侧背外侧前额叶皮层，T=-3.02，p=0.014；左侧额极皮层，T=-4.37，p=0.002；右侧背外侧前额叶皮层，T=-2.59，p=0.027）、韩语颜色词斯特鲁普测试（左侧眶额皮层，T=-3.61，p=0.009）和社会事件记忆测试（左侧背外侧前额叶皮层，T=-2.35，p=0.043；左侧额极皮层，T=-3.35，p=0.01）。
我们的结果显示乌地那非对老年人大脑血液动力学有矛盾的影响。这与我们的假设相矛盾，但表明 fNIRS 对 PDE5I 引起的大脑血液动力学变化敏感。
