环状及非环状亚硝胺和仲胺对大鼠肝脏二甲基亚硝胺脱甲基酶的抑制作用。

Inhibition of rat hepatic dimethylnitrosamine demethylase by cyclic and acyclic nitrosamines and secondary amines.

作者信息

Chau I Y, Archer M C

出版信息

Experientia. 1978 Nov 15;34(11):1505-6. doi: 10.1007/BF01932378.

DOI:10.1007/BF01932378

PMID:720488

Abstract

Inhibition of hepatic dimethylnitrosamine (DMN) metabolism by a variety of cyclic and acyclic nitrosamines was demonstrated. Nitrosoproline, a noncarcinogenic nitrosamine, behaved differently from the carcinogenic nitrosamines as an inhibitor for DMN-demethylase. Secondary amines corresponding to the nitrosamines inhibited DMN-demethylase in a manner similar to the nitrosamines.

摘要

已证实多种环状和非环状亚硝胺可抑制肝脏二甲基亚硝胺（DMN）的代谢。亚硝基脯氨酸是一种非致癌性亚硝胺，作为DMN脱甲基酶的抑制剂，其表现与致癌性亚硝胺不同。与亚硝胺相对应的仲胺以与亚硝胺相似的方式抑制DMN脱甲基酶。