Wang Gui-qing, Qian Guo-zheng, Yang Yong-ju, Wang Yan, Yu Xue-hai, Guo Ji-ping, Wang Su-chun
Shanghai Institute of Cerebral Vascular Disease Prevention and Care, Shanghai 200433, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Feb;24(2):98-101.
To study the reference range of cerebrovascular hemodynamics indexes (CVHI) in a sampling population.
Fourteen thousand, four hundred and eighty participants without history of stroke or exposure to risk factors were screened from 26 cities in Northeast China, North China, East China, Northwest China, South China, and Southwest China in the prospective study on stroke intervention. CVHI were checked and 95% confidence intervals were calculated using normal distribution methods, which were grouped by age, sex, area, and check positions.
Characteristics of CVHI 95% confidence intervals showed that low limit of carotid blood velocity as V(max), V(min), V(mean) decreased, but upper limit of cerebral RV, Zcv, WV, DR and CP increased with the increase of age. However, Q(mean) and DP did not show significant trends of age difference. Low limit of Q(mean), V(max) and upper limit of RV, DR, CP and DP in males were higher than that in females while upper limit of WV and Zcv in females were higher than that in males. Left carotid low limit of Q(mean), V(mean), V(max), V(min), and upper limit of WV, Zcv and CP were higher than that of the right but upper limit of RV, DR and DP were lower than that of the right. There were no obvious differences between areas.
Obvious differences of CVHI 95% confidence intervals ranges were found between age groups, sex, and checking positions, respectively, suggesting that the reference ranges of CVHI to be estimated by every subgroup.
研究抽样人群脑血管血流动力学指标（CVHI）的参考范围。
在前瞻性卒中干预研究中，从中国东北、华北、华东、西北、华南和西南地区的26个城市筛选出14480名无卒中病史或无危险因素暴露史的参与者。检测CVHI，并采用正态分布方法计算95%置信区间，按年龄、性别、地区和检测部位进行分组。
CVHI 95%置信区间的特征显示，随着年龄的增加，颈动脉血流速度的下限如V（max）、V（min）、V（mean）降低，但脑血流阻力（RV）、脑血管阻力（Zcv）、血流加权值（WV）、动态阻力（DR）和临界压力（CP）的上限升高。然而，平均血流量（Q（mean））和舒张压（DP）未显示出明显的年龄差异趋势。男性的Q（mean）、V（max）下限以及RV、DR、CP和DP上限高于女性，而女性的WV和Zcv上限高于男性。左颈动脉的Q（mean）、V（mean）、V（max）、V（min）下限以及WV、Zcv和CP上限高于右侧，但RV、DR和DP上限低于右侧。各地区之间无明显差异。
CVHI 95%置信区间范围在年龄组、性别和检测部位之间分别存在明显差异，提示应按每个亚组估计CVHI的参考范围。
