通过抗体依赖性增强巨噬细胞感染来抑制抗病毒反应。
Suppression of antiviral responses by antibody-dependent enhancement of macrophage infection.
作者信息
Suhrbier Andreas, La Linn May
机构信息
Queensland Institute of Medical Research and the Australian Centre for International & Tropical Health & Nutrition, 300 Herston Road, Herston, Queensland 4029, Australia.
出版信息
Trends Immunol. 2003 Apr;24(4):165-8. doi: 10.1016/s1471-4906(03)00065-6.
Antibody-dependent enhancement (ADE) of macrophage and monocyte infection has been demonstrated in vitro for some of the most deadly RNA viruses known. Recent evidence suggests that ADE-mediated ligation of Fc receptors might suppress host-cell antiviral gene expression by promoting early interleukin-10 (IL-10) secretion, resulting in the expression of suppressor-of-cytokine-signalling (SOCS) proteins and a Th2 bias. These findings provide potential new insights into how ADE might enhance viral infections and exacerbate disease.
对于一些已知的最致命RNA病毒，体外实验已证实巨噬细胞和单核细胞感染存在抗体依赖增强（ADE）现象。最近的证据表明，ADE介导的Fc受体连接可能通过促进早期白细胞介素-10（IL-10）分泌来抑制宿主细胞抗病毒基因表达，从而导致细胞因子信号抑制蛋白（SOCS）的表达及Th2偏向。这些发现为ADE如何增强病毒感染和加重疾病提供了潜在的新见解。
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