Laboratory Centre, Xiamen University Malaysia, Sepang, Malaysia.
Department of Medical Microbiology, Faculty Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Front Immunol. 2022 Jul 6;13:889196. doi: 10.3389/fimmu.2022.889196. eCollection 2022.
The dynamics of host-virus interactions, and impairment of the host's immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.
宿主-病毒相互作用的动态，以及登革热病毒（DENV）血清型对宿主免疫监视的损害在很大程度上仍然不清楚。一些实验和临床前研究已经表明，病毒如何通过激活免疫细胞和炎症级联反应的其他关键因素导致严重疾病。浆母细胞在初次和二次感染期间被激活，并在重症登革热中发挥决定性作用。DENV 免疫反应与其他黄病毒的交叉反应性既可能对交叉保护和疾病严重程度产生影响。DENV 和抗 SARS-CoV-2 反应之间的交叉反应的后果在流行地区具有高度相关性。在这里，我们综述了对登革热免疫发病机制的最新理解进展，并为针对登革热的靶向策略的发展提供了建议。
