马赛 - 长岛血红蛋白与糖化血红蛋白（HbA1c）的解读：哪个HbA1c结果才是“正确答案”？

Haemoglobin Marseille-Long Island and interpretation of HbA1c: which HbA1c result is the "right answer"?

作者信息

Florkowski C M, Walmsley T A, Brennan S O, George P M

机构信息

Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand.

出版信息

Postgrad Med J. 2003 Mar;79(929):174-5. doi: 10.1136/pmj.79.929.174.

DOI:10.1136/pmj.79.929.174

PMID:12697922

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1742634/

Abstract

A woman was screened for diabetes using glycated haemoglobin (HbA1c). Vastly different results were obtained by high performance liquid chromatography (45%), immunoassay (2.9%), and affinity chromatography (4.2%) compared with the non-diabetic range of less than 6.4%. Mass spectral studies confirmed the presence a haemoglobin variant, haemoglobin Marseille-Long Island which had confounded interpretation by all methods.

摘要

一名女性接受了糖化血红蛋白（HbA1c）检测以筛查糖尿病。与非糖尿病范围低于6.4%相比，采用高效液相色谱法（45%）、免疫分析法（2.9%）和亲和色谱法（4.2%）得出的结果差异很大。质谱研究证实存在一种血红蛋白变体，即马赛-长岛血红蛋白，它干扰了所有方法的解读。