宫内节育器对兔胚泡细胞核脱氧核糖核酸代谢的影响：一项放射自显影研究。

Effects of intrauterine devices on nuclear deoxyribonucleic acid metabolism in rabbit blastocysts: an autoradiographic study.

作者信息

Mizumoto H, Hohman W R, Moyer D L

出版信息

Fertil Steril. 1976 Apr;27(4):449-58. doi: 10.1016/s0015-0282(16)41784-x.

Abstract

A metabolic parameter, DNA synthesis, was measured in rabbit blastocysts exposed to Silastic intrauterine devices (IUDs) and compared with those without IUD exposure. Autoradiographic detection of 3H-thymidine uptake showed that the IUD-exposed blastocysts contained fewer labeled cells than their IUD-free equivalents. The depressed DNA synthesis may be caused by either a block in the cell cycle or a block in DNA synthesis itself. Either way, the result could be consistent with the observation that embryo deaths occur at all growth stages, preimplantation, during implantation, and postimplantation.

摘要

对暴露于硅橡胶宫内节育器（IUD）的兔胚泡的代谢参数DNA合成进行了测量，并与未暴露于IUD的兔胚泡进行了比较。通过放射自显影检测3H-胸腺嘧啶核苷摄取量，结果显示，与未接触IUD的胚泡相比，接触IUD的胚泡中标记细胞较少。DNA合成受抑制可能是由于细胞周期阻滞或DNA合成本身受阻。无论哪种情况，这一结果都与胚胎在所有生长阶段（植入前、植入期间和植入后）均会死亡的观察结果相符。