Wellwood J M, Ellis B G, Hall J H, Robinson D R, Thompson A E
Br Med J. 1973 May 5;2(5861):261-5. doi: 10.1136/bmj.2.5861.261.
The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), beta-galactosidase (GAL), beta-glucosidase (GLU), and alkaline phosphatase (AP) was studied in 83 patients with renal allografts. Thirty of these patients had stable graft function and their urinary enzyme levels provided a range of normal values. Urinary lactic dehydrogenase (LDH) was estimated in 29 normal subjects and in 11 patients with renal allografts. Serum values for the five enzymes were also obtained. Urinary NAG excretion was abnormally high in 16 out of 17 (94%) episodes of acute rejection. The other urinary enzymes were raised less frequently. In nine patients studied before the onset of rejection urinary NAG activity rose up to three weeks before changes in other tests of renal function. Serum enzyme levels were not found to be of value in the diagnosis of rejection.
对83例肾移植患者的N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、β-半乳糖苷酶（GAL）、β-葡萄糖苷酶（GLU）和碱性磷酸酶（AP）的尿排泄情况进行了研究。其中30例患者移植肾功能稳定，其尿酶水平提供了一系列正常值。对29名正常受试者和11例肾移植患者的尿乳酸脱氢酶（LDH）进行了评估。还获得了这五种酶的血清值。在17次急性排斥反应发作中的16次（94%），尿NAG排泄异常升高。其他尿酶升高的频率较低。在9例排斥反应发作前进行研究的患者中，尿NAG活性在其他肾功能检查出现变化前长达三周就升高了。血清酶水平在排斥反应的诊断中未发现有价值。
